May 9th, 2017

Mike's paper 2017

Congratulations to Mike for his publication in Journal of Neurodevelopmental Disorders. He rigorously quantified EEG abnormality in individuals with Angelman syndrome (AS) and AS model mice and pinpointed that delta rhythmicity phenotypes can serve as reliable biomarkers for AS in both preclinical and clinical settings.

Please click here to read the article. 


March 8th, 2017

MBL

Congratulations to Sally Kim for being accepted to the prestigious Neural Systems and Behavior summer course at Marine Biological Laboratory!


Aug 2nd, 2016

Motor mishape: Mice missing the gene UBE3a (right) have thinner fibers in a nerve bundle called the corpus callosum than controls do (left). Matt Judson and Alain Burette, UNC

“Unusually thin nerve fibers in the brain may underlie the motor difficulties seen in some children with Angelman syndrome, an autism-related condition. The findings point to a possible new biomarker for the condition, and even a road toward a treatment.”

“The findings hint that normalizing UBE3A expression in people with Angelman syndrome might repair a key structural problem in their brains. “If we can add the gene back early enough, then we might be able to reverse the white matter deficits or prevent them from continuing to emerge,” says Benjamin Philpot, associate director of the Neuroscience Center at the University of North Carolina at Chapel Hill, who presented the findings.”

Please click here to read the article


July 4th, 2016

Kelly’s recent publication in Angelman syndrome is highlighted in Spectrum. “A newly discovered phenomenon in cells that regulate the sleep-wake cycle may provide clues for how to treat Angelman syndrome and dup15q syndrome, two autism-related conditions.”
Please click the figure below to read the article.


June 16th, 2016

Congratulations to Kelly for her new Angelman syndrome publication! She found that neurons in the suprachiasmatic nucleus (SCN) maintain persistent expression of paternal UBE3A protein, suggesting a relaxation of Ube3a imprinting in the SCN that is not typical of most neurons. Her paper marks Philpot lab’s 5th publication of the year!

Jones KA, Han JE, DeBruyne JP, Philpot BD (2016) Persistent neuronal Ube3a expression in the suprachiasmatic nucleus of Angelman syndrome model mice. Scientific Reports 6:28238.


May 27th, 2016

Congratulations to Angie for her publication in PLoS ONE! She discovered Topoisomerase 1, creating cleavage complexes, -dependent and -independent control of gene expression and Ube3a regulation in neurons.

Mabb AM, Simon JM, King IF, Lee H-M, An L-K, Philpot BD, and Zylka MJ. (2016) Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms. PLoS ONE 11(5): e0156439. doi:10.1371/journal.pone.0156439


Apr 27th, 2016

Congratulations to Sally (Hyojin) and Portia for the new Angelman syndrome publication in the Journal of Neuroscience!

To read the article, follow this link.


Apr 6th, 2016

Dr. Matt Judson’s study is highlighted on the cover of the April 6th issue of Neuron.

NEURON_90_1.c1.indd
Click the cover image to the article.


Mar 24th, 2016

Congratulations to Dr. Matt Judson for his paper published in Neuron. His discoveries are featured in the UNC health Care and School of Medicine news. Please click here to read the news article.

To read the paper, follow this link.


Feb 29th, 2016

Our lab is supporting for Rare Disease Day!

DSCN1732 Rare Disease Day

Rare Disease Day takes place on the last day of February each year. The main objective is to raise awareness amongst the general public and decision-makers about rare diseases and their impact on patients’ lives. The campaign targets primarily the general public and also seeks to raise awareness amongst policy makers, public authorities, industry representatives, researchers, health professionals and anyone who has a genuine interest in rare diseases. Visit the website for more info.


Feb 17th, 2016

Philpot and Stuber labs discover a role for GABA co-release in the brain’s reward pathway

In a paper published in Nature Communications, Janet Berrios, a graduate student in the Philpot lab, discovered that the loss of UBE3A decreases the release of the GABA neurotransmitter and alters reward-seeking behavior in an important neural pathway once presumed to be principally regulated by the dopamine neurotransmitter. To read the article, visit the website.


Jan 20th, 2016

Zylka and Philpot to lead UNC Neuroscience Center

Mark Zylka, PhD, will serve as director and Ben Philpot, PhD, will serve as associate director of the UNC Neuroscience Center at the UNC School of Medicine, effective July 1. William Snider, MD, who has served as the center’s director for nearly 17 years, will step down from his leadership role, but will remain on faculty as professor of neurology, while also continuing his research.