May 3rd, 2018
Congratulations to Hanna and Mike for their new publication! This is Mike’s second first author publication of the year!! Hanna was a visiting researcher from the Netherlands for 6 months. During her time in the lab, she collaborated with Mike and developed the automated approach to assess long- and short-range functional connectivity by measuring coherence across multiple frequencies during wake and sleep. Using this program, they found that during wakefulness, children with AS showed enhanced long-range EEG coherence across a wide range of frequencies. During sleep, children with AS showed increased long-range EEG coherence specifically in the gamma band. Please click this link to read the full article.
March 14th, 2018
Congratulations to Mike for his new publication! The study focused on behaviors encoded by the prefrontal cortex, a region broadly involved in executive function and cognition, in the mouse model of Angelman syndrome. To read the article, please click this link.
January 24th, 2018
Congratulations on Courtney and Alex for the new Pitt-Hopkins syndrome (PTHS) publication on J Neuroscience! Courtney, Alex, and other authors generated two novel mouse models of PTH, which mimics the most common pathogenic TCF4 point mutation. The authors thoroughly investigated behavioral and physiological phenotypes on those models and found that those mouse models exhibited hippocampal NMDA receptor hyperfunction. To read more detail, please click this link.
October 14th, 2017
October 7, 2017 was a big day for Logan’s family, especially for Logan. She was chosen by UNC Children’s Hospital for the coin toss at the University of North Carolina’s football game against Notre Dame. Logan was diagnosed with Pitt Hopkins syndrome (PTHS) in 2015, a rare genetic neurodevelopmental disorder caused by a mutation of a specific gene, TCF4. There are approximately 700 individuals diagnosed worldwide. Logan’s family took the opportunity to raise awareness of the disorder and to set the fundraising. Dr. Ben Philpot was invited to be part of Logan’s big day!
August 2nd, 2017
Congratulations to Dr.Matt Judson for his new publication in Journal of Neuroscience. Matt analyzed brain structure in a maternal Ube3a knock-out mouse model of AS. He reported that the volume of white matter (WM) is disproportionately reduced in AS mice, indicating that deficits in WM development are a major factor underlying impaired brain growth and microcephaly in the disorder.
Please click here to read the article.
May 9th, 2017
Congratulations to Mike for his publication in Journal of Neurodevelopmental Disorders. He rigorously quantified EEG abnormality in individuals with Angelman syndrome (AS) and AS model mice and pinpointed that delta rhythmicity phenotypes can serve as reliable biomarkers for AS in both preclinical and clinical settings.
Please click here to read the article.
March 8th, 2017
Congratulations to Sally Kim for being accepted to the prestigious Neural Systems and Behavior summer course at Marine Biological Laboratory!
Aug 2nd, 2016
“Unusually thin nerve fibers in the brain may underlie the motor difficulties seen in some children with Angelman syndrome, an autism-related condition. The findings point to a possible new biomarker for the condition, and even a road toward a treatment.”
“The findings hint that normalizing UBE3A expression in people with Angelman syndrome might repair a key structural problem in their brains. “If we can add the gene back early enough, then we might be able to reverse the white matter deficits or prevent them from continuing to emerge,” says Benjamin Philpot, associate director of the Neuroscience Center at the University of North Carolina at Chapel Hill, who presented the findings.”
Please click here to read the article
July 4th, 2016
Kelly’s recent publication in Angelman syndrome is highlighted in Spectrum. “A newly discovered phenomenon in cells that regulate the sleep-wake cycle may provide clues for how to treat Angelman syndrome and dup15q syndrome, two autism-related conditions.”
Please click the figure below to read the article.
June 16th, 2016
Congratulations to Kelly for her new Angelman syndrome publication! She found that neurons in the suprachiasmatic nucleus (SCN) maintain persistent expression of paternal UBE3A protein, suggesting a relaxation of Ube3a imprinting in the SCN that is not typical of most neurons. Her paper marks Philpot lab’s 5th publication of the year!
Jones KA, Han JE, DeBruyne JP, Philpot BD (2016) Persistent neuronal Ube3a expression in the suprachiasmatic nucleus of Angelman syndrome model mice. Scientific Reports 6:28238.
May 27th, 2016
Congratulations to Angie for her publication in PLoS ONE! She discovered Topoisomerase 1, creating cleavage complexes, -dependent and -independent control of gene expression and Ube3a regulation in neurons.
Mabb AM, Simon JM, King IF, Lee H-M, An L-K, Philpot BD, and Zylka MJ. (2016) Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms. PLoS ONE 11(5): e0156439. doi:10.1371/journal.pone.0156439
Apr 27th, 2016
Congratulations to Sally (Hyojin) and Portia for the new Angelman syndrome publication in the Journal of Neuroscience!
To read the article, follow this link.
Apr 6th, 2016
Dr. Matt Judson’s study is highlighted on the cover of the April 6th issue of Neuron.
Mar 24th, 2016
Congratulations to Dr. Matt Judson for his paper published in Neuron. His discoveries are featured in the UNC health Care and School of Medicine news. Please click here to read the news article.
To read the paper, follow this link.
Feb 29th, 2016
Our lab is supporting for Rare Disease Day!
Rare Disease Day takes place on the last day of February each year. The main objective is to raise awareness amongst the general public and decision-makers about rare diseases and their impact on patients’ lives. The campaign targets primarily the general public and also seeks to raise awareness amongst policy makers, public authorities, industry representatives, researchers, health professionals and anyone who has a genuine interest in rare diseases. Visit the website for more info.
Feb 17th, 2016
In a paper published in Nature Communications, Janet Berrios, a graduate student in the Philpot lab, discovered that the loss of UBE3A decreases the release of the GABA neurotransmitter and alters reward-seeking behavior in an important neural pathway once presumed to be principally regulated by the dopamine neurotransmitter. To read the article, visit the website.
Jan 20th, 2016
Mark Zylka, PhD, will serve as director and Ben Philpot, PhD, will serve as associate director of the UNC Neuroscience Center at the UNC School of Medicine, effective July 1. William Snider, MD, who has served as the center’s director for nearly 17 years, will step down from his leadership role, but will remain on faculty as professor of neurology, while also continuing his research.